How To run An MSU file Posted on by Webmaster IT Support Forum › Forums › Windows › Windows 10 › Troubleshooting › How To run An MSU file Tagged: MSU, Wusa This topic contains 0 replies, has 1 voice, and was last updated by Webmaster 3 years ago. Author Posts February 16, 2016 at 9:43 am #1709 WebmasterKeymaster Double clicking an MSU file doesn’t always run it. To run an MSU file, run this command in the command prompt: wusa C:\file.msu (Where C:\file.msu is the path to the MSU file you want to run). To launch the command prompt, type cmd then enter, after hitting the Start button. The MSU file will then run. Author Posts You must be logged in to reply to this topic.