In April 2015, Google released a patch to Chrome that disables NPAPI by default. This stops many applications from working. To enable NPAPI in Google Chrome:
Open Google Chrome
In the address bar, type chrome://flags/#enable-npapi and press enter
Under Enable NPAPI, click Enable
Scroll to the bottom of the page and click Relaunch Now
NPAPI will now be enabled in Google Chrome.
To enable NPAPI in Google Chrome across the enterprise, I imagine you’d have to use a packaging tool or something to monitor changes to Windows (files and registry) to find where Google Chrome stores the setting to enable NPAPI. Once you have this, you could make a reg file or exe to deploy via group policy to enable NPAPI across all your computers. Alternatively you could make an ADM template (I’m assuming that there isn’t already one by the time you are reading this).
If you do find the location Google Chrome stores the setting to enable NPAPI or if you discover a GPO, please leave a message in the forum to help others.